Improved Oxygenation in a Randomized Trial of Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn
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چکیده
منابع مشابه
Improved oxygenation in a randomized trial of inhaled nitric oxide for persistent pulmonary hypertension of the newborn.
OBJECTIVE To determine the effect of inhaled nitric oxide (NO) on clinical outcome in newborns with persistent pulmonary hypertension (PPHN). DESIGN A prospective, randomized trial of patients referred to a level 3 nursery in a single large center. Clinicians were not masked to group assignment. Crossover of patients from control to NO treatment was not permitted. METHODS We randomized 49 m...
متن کاملInhaled nitric oxide in persistent pulmonary hypertension of the newborn.
Nitric oxide (NO) has vasodilatory effects on the pulmonary vasculature in adults and animals. We examined the effects on systemic oxygenation and blood pressure of inhaling up to 80 parts per million by volume of NO at FiO2 0.9 for up to 30 minutes by 6 infants with persistent pulmonary hypertension of the newborn (PPHN). In all infants this treatment rapidly and significantly increased preduc...
متن کاملInhaled nitric oxide in the management of persistent pulmonary hypertension of the newborn: a meta-analysis.
OBJECTIVES To evaluate the use of inhaled nitric oxide (NO) in the management of persistent pulmonary hypertension of the newborn. METHODS Computerized bibliographic search on MEDLINE, CURRENT CONTENTS and LILACS covering the period from January 1990 to March 1998; review of references of all papers found on the subject. Only randomized clinical trials evaluating nitric oxide and conventional...
متن کاملInhaled nitric oxide reduces the utilization of extracorporeal membrane oxygenation in persistent pulmonary hypertension of the newborn.
OBJECTIVE To determine if the use of inhaled nitric oxide therapy reduces the need for extracorporeal membrane oxygenation (ECMO) in persistent pulmonary hypertension of the newborn. DESIGN A matched cohort study with retrospective data extraction. SETTING Pediatric and neonatal intensive care units at a medical school-affiliated children's hospital serving as a regional referral center for...
متن کاملWeaning strategy with inhaled nitric oxide treatment in persistent pulmonary hypertension of the newborn.
AIM To determine if infants who had become dependent on inhaled nitric oxide treatment could be successfully weaned off it if FIO2 was increased briefly during withdrawal. METHODS Sixteen infants admitted for conditions associated with increased pulmonary vascular resistance responded well to inhaled nitric oxide treatment with a significant increase in PaO2 (maximum inhaled nitric oxide give...
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ژورنال
عنوان ژورنال: PEDIATRICS
سال: 1997
ISSN: 0031-4005,1098-4275
DOI: 10.1542/peds.100.5.e7